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Constipation is a very rare side effect that happens due to a drug’s anticholinergic effect, which means the drug blocks neurotransmitters that affect how the body functions. In this case, certain receptors that help gut motility are blocked. This side effect was much more common with older, first-generation antihistamines such as Benadryl, says Dr. Patel.
It’s not as common with Zyrtec, but if this does happen to you, Dr. Eitches recommends trying a different antihistamine, adding fiber to your diet, and staying well-hydrated to get things moving again.
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